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Did you mean Gasdermin C (gsdme) (68 results)?
PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis.
Hou J, Zhao R, Xia W, Chang CW, You Y, Hsu JM, Nie L, Chen Y, Wang YC, Liu C, Wang WJ, Wu Y, Ke B, Hsu JL, Huang K, Ye Z, Yang Y, Xia X, Li Y, Li CW, Shao B, Tainer JA, Hung MC. Hou J, et al. Nat Cell Biol. 2020 Oct;22(10):1264-1275. doi: 10.1038/s41556-020-0575-z. Epub 2020 Sep 14. Nat Cell Biol. 2020. PMID: 32929201 Free PMC article.
Under hypoxia, p-Stat3 physically interacts with PD-L1 and facilitates its nuclear translocation, enhancing the transcription of the gasdermin C (GSDMC) gene. GSDMC is specifically cleaved by caspase-8 with TNFalpha treatment, generating a GSDMC …
Under hypoxia, p-Stat3 physically interacts with PD-L1 and facilitates its nuclear translocation, enhancing the transcription of the gasd …
Gasdermin C sensitizes tumor cells to PARP inhibitor therapy in cancer models.
Wang S, Chang CW, Huang J, Zeng S, Zhang X, Hung MC, Hou J. Wang S, et al. J Clin Invest. 2024 Jan 2;134(1):e166841. doi: 10.1172/JCI166841. J Clin Invest. 2024. PMID: 37883181 Free PMC article.
However, resistance to PARPi is frequently observed in the clinic due to an incomplete understanding on the molecular basis of PARPi function and a lack of good markers, beyond BRCA mutations, to predict response. Here, we show that gasdermin C (GSDMC) sensit …
However, resistance to PARPi is frequently observed in the clinic due to an incomplete understanding on the molecular basis of PARPi functio …
Epithelial STAT6 O-GlcNAcylation drives a concerted anti-helminth alarmin response dependent on tuft cell hyperplasia and Gasdermin C.
Zhao M, Ren K, Xiong X, Xin Y, Zou Y, Maynard JC, Kim A, Battist AP, Koneripalli N, Wang Y, Chen Q, Xin R, Yang C, Huang R, Yu J, Huang Z, Zhang Z, Wang H, Wang D, Xiao Y, Salgado OC, Jarjour NN, Hogquist KA, Revelo XS, Burlingame AL, Gao X, von Moltke J, Lin Z, Ruan HB. Zhao M, et al. Immunity. 2022 Apr 12;55(4):623-638.e5. doi: 10.1016/j.immuni.2022.03.009. Epub 2022 Apr 5. Immunity. 2022. PMID: 35385697 Free PMC article.
Meanwhile, STAT6 O-GlcNAcylation activated the expression of Gsdmc family genes. The membrane pore formed by GSDMC facilitated the unconventional secretion of IL-33. GSDMC-mediated IL-33 secretion was indispensable for effective anti-helminth immunity and con …
Meanwhile, STAT6 O-GlcNAcylation activated the expression of Gsdmc family genes. The membrane pore formed by GSDMC facilitated …
Detection of Gasdermin C-Mediated Cancer Cell Pyroptosis.
Hou J, Wang S, Miao R, Zhang X, Hung MC. Hou J, et al. Methods Mol Biol. 2023;2641:135-146. doi: 10.1007/978-1-0716-3040-2_11. Methods Mol Biol. 2023. PMID: 37074647
Cleavage of a gasdermin by an active protease causes lytic cell death. Gasdermin C (GSDMC) is cleaved by caspase-8 in response to macrophage-secreted TNF-alpha. ...GSDMC cleavage, LDH release, and plasma membrane translocation of GSDMC-N …
Cleavage of a gasdermin by an active protease causes lytic cell death. Gasdermin C (GSDMC) is cleaved by caspase …
The Versatile Gasdermin Family: Their Function and Roles in Diseases.
Zou J, Zheng Y, Huang Y, Tang D, Kang R, Chen R. Zou J, et al. Front Immunol. 2021 Nov 11;12:751533. doi: 10.3389/fimmu.2021.751533. eCollection 2021. Front Immunol. 2021. PMID: 34858408 Free PMC article. Review.
The gasdermin (GSDM) family, a novel group of structure-related proteins, consists of GSDMA, GSDMB, GSDMC, GSDMD, GSDME/DNFA5, and PVJK/GSDMF. GSDMs possess a C-terminal repressor domain, cytotoxic N-terminal domain, and flexible linker domain (except for GSD …
The gasdermin (GSDM) family, a novel group of structure-related proteins, consists of GSDMA, GSDMB, GSDMC, GSDMD, GSDME/DNFA5, …
The expression profile of Gasdermin C-related genes predicts the prognosis and immunotherapy response of pancreatic adenocarcinoma.
Xia XH, Yin WJ, Mao JF, Liu P, Qin CD, Hu JJ, Liu SY, Wang CM, Zou DH, Yang HJ, Yu Y, Huang J. Xia XH, et al. Am J Cancer Res. 2023 Apr 15;13(4):1240-1258. eCollection 2023. Am J Cancer Res. 2023. PMID: 37168356 Free PMC article.
Pancreatic adenocarcinoma (PAAD) has a poor prognosis and is relatively unresponsive to immunotherapy. Gasdermin C (GSDMC) induces pyroptosis in cancer cells and inflammation in the tumor microenvironment. ...Moreover, the overexpression of GSDMC was r …
Pancreatic adenocarcinoma (PAAD) has a poor prognosis and is relatively unresponsive to immunotherapy. Gasdermin C (GSDMC …
Ultraviolet light-induced gasdermin C expression is mediated via TRPV1/calcium/calcineurin/NFATc1 signaling.
Kusumaningrum N, Lee DH, Yoon HS, Park CH, Chung JH. Kusumaningrum N, et al. Int J Mol Med. 2018 Nov;42(5):2859-2866. doi: 10.3892/ijmm.2018.3839. Epub 2018 Aug 24. Int J Mol Med. 2018. PMID: 30226565
Gasdermin (GSDM)-C is a member of the GSDM gene family and is expressed in the epithelial cells of various tissue types, including skin. ...These data suggested that TRPV1 may serve an important role in the induction of GSDMC expression by UV and that UV-indu …
Gasdermin (GSDM)-C is a member of the GSDM gene family and is expressed in the epithelial cells of various tissue types, inclu …
Gasdermin C is induced by ultraviolet light and contributes to MMP-1 expression via activation of ERK and JNK pathways.
Kusumaningrum N, Lee DH, Yoon HS, Kim YK, Park CH, Chung JH. Kusumaningrum N, et al. J Dermatol Sci. 2018 May;90(2):180-189. doi: 10.1016/j.jdermsci.2018.01.015. Epub 2018 Feb 1. J Dermatol Sci. 2018. PMID: 29428815
UV has been shown to regulate the expressions of many genes including matrix metalloproteinases (MMPs). Gasdermin C (GSDMC) belongs to Gasdermin family and is known to be expressed in the epithelial cells of many tissues including the skin. However, th …
UV has been shown to regulate the expressions of many genes including matrix metalloproteinases (MMPs). Gasdermin C (GSDMC …
Pyroptosis, inflammasome, and gasdermins in tumor immunity.
Ouyang X, Zhou J, Lin L, Zhang Z, Luo S, Hu D. Ouyang X, et al. Innate Immun. 2023 Jan;29(1-2):3-13. doi: 10.1177/17534259221143216. Epub 2023 Jan 11. Innate Immun. 2023. PMID: 36632024 Free PMC article. Review.
The gasdermins (GSDM), a family of pore-forming proteins, consist of gasdermin A (GSDMA), gasdermin B (GSDMB), gasdermin C (GSDMC), gasdermin D (GSDMD), gasdermin E (GSDME) and DFNB59 (Pejvakin (PJVK)) in humans. ...In this …
The gasdermins (GSDM), a family of pore-forming proteins, consist of gasdermin A (GSDMA), gasdermin B (GSDMB), gasde …
26 results